| Study | Country | Type of tumour | SNP | Exposures,Biomarkers,Others |
|---|---|---|---|---|
| Turin Bladder cancer study Principal Investigator: Giuseppe Matullo, Data on 350 cases and 350 controls regarding lifestile variables (smoking, diet) and DNA polymorphisms (DNA repair and metabolic genes); DNA adducts on a subset of subjects. | Italy | Bladder cancer | XRCC2_31479_A_G rs3218536 XPD_ERCC2_23591_G_A_ex23 rs1799793 XPD_ERCC2_35931_C_A_ex23 rs13181 PCNA_6084_G_C rs3626 XRCC1_26304_T_C rs1799782 XRCC1_26651_G_A rs915927 XRCC1_28152_G_A_ex10 rs25487 XRCC1 rs1001581 XRCC3_4541_C_T rs1799794 XRCC3_17893_A_G rs1799796 XRCC3_18067_C_T_ex7 rs86153 APEX_1738_T_G rs1130409 ERCC1_19007_C_T rs11615 XPA_23_A_G rs1800975 XPC_PAT ERCC4_30028_C_T_Ser835Ser rs1799 ERCC4_30147_G_A_Glu875Gly rs1800 XRCC1 rs2854501 ERCC1 rs2336219 ERCC1 rs3212955 ERCC1 rs735482 ERCC2 rs171140 ERCC2 rs1799787 ERCC2 rs3916874 ERCC1 rs967591 ERCC2 rs1052555 NAT2_T_C rs1041983 NAT2_T_C rs1801280 | sex age race ethnicity smoking |
| Parallel 24-day dietary study Principal Investigator: Steffen Loft, A parallel placebo-controlled intervention study in which subjects were randomized into three groups receiving an antioxidant-free basal diet and 600 g of fruits and vegetables, or a supplement containing the corresponding amounts of vitamins | Denmark | Sex Diet (Vitamins, Minerals) Ogg1 repair activity 5 day sunflux prior to measurement 10 day sunflux prior to measurement 30 day sunflux prior to measurement OGG1 (mRNA) ERCC1 (mRNA) 8oxodG excretion DNA strand breaks EndoIII sites FPG sites H2O2 sites | ||
| NLCS GENRE Principal Investigator: P.A. Van Den Brandt, This dataset contains information of the mutational status of the VHL-gene in 235 cases with renal cell cancer from the Netherlands Cohort Study on Diet and Cancer. | Netherland | Renal Cell cancer | Mutation in the VHL gene | sex |
| NLCS CREAM Principal Investigator: P.A. Van Den Brandt, This dataset contains information of the mutational status of the KRAS and APC genes and on expression of MLH1 of 734 cases with colorectal cancer from the Netherlands Cohort Study on Diet and Cancer. | Netherland | Colorectal cancer | KRAS mutation KRAS activating mutation APC stop codon mutation APC mutation | sex age MLH1 expression |
| NIEH Lung cancer study Principal Investigator: Bernadette Schoket, 162 cases of cancer were observed. Data collected include: smoking habits, gender, cellular damage and genotypes for 14 SNPs | Hungary | Lung Cancer | CYP2S1 MPO_463G__A CYP1A1Ile462Val NQO1_Pro187Ser GSTT1 CYP1A1_MspI GSTM1 GSTP1_Ile105_Val CYP1B1_Leu432Val CYP2C9_Arg144Cys CYP2C9_Ile359Leu XRCC1_Arg399Gln p53_Arg72Pro_exon4 XPG_1104 XPD_751 KRAS mutation (lung tumour tissue) KRAS mutation (lung normal tissue) MTHFR_C677T P53 Mutation | age sex smoking DNA Adducts (32P postlabelling - lung tumour tissue) DNA Adducts (32P postlabelling - bronchial tissue) DNA Adducts (32P postlabelling - lung normal tissue) DNA Adducts (32P postlabelling - limphocyte) DNA Adducts (32P postlabelling - border tumour tissue) CIA Adducts (lung tumour tissue) CIA Adducts (lung normal tissue) O4-etT Postlabelling Adducts |
| GENAIR Principal Investigator: Paolo Vineis, The study was established to investigate molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke, looking at non-smokers in EPIC. | Italy | Leukemia, Lung and Bladder cancer | XPD23591x rs1799793 XPD35931x rs13181 PCNA6084x rs3626 X1_26304x rs1799782 X1_26651x rs915927 X1_28152x rs25487 X3_17893x rs1799796 X3_18067x rs86153 APX_1738x rs1130409 E1_19007x rs11615 MG127215x rs12917 OG1_8055x BRCA1x BRCA2x NBS1x RAD51x RAD512x RAD52x XRCC2x rs3218536 LIG4x LIG45x t_p53x mnSODy NQO1y COMTy MPOy SULT_1A1y GSTM3y GSTP1_105y GSTP1_114y cyp1a1y cyp1b1y GSTT1y GSTM1y nat2y | Road traffic exposure DNA Adducts (32P postlabelling) |
| FIOH BC AH Principal Investigator: Ari Hirvonen, Data on breast cancer: 964 cases and controls with genotype data about SNPs of GST, NAT, VDR, XRCC1, XPD, CYP17, COMT, MnSOD, SULTA1. Besides, informations about gender and smoking is provided. | Finland | Breast cancer | GSTM1 GSTT1 GSTP1 GSTM3 GSTM3_63AC NAT1 NAT2 NAT2_282 NAT2_341 VDRTaqI VDRBsmI VDRApaI CYP17 COMT MnSOD SULT1A1 XRCC1280 XRCC1399 XPD | sex smoking age |
| EPIC Spain Principal Investigator: Antonio Agudo, The database consists of 296 subjects for which we measured DNA adducts (by 32P-postlabelling) and SNPs in some metabolic genes. | Spain | CYP1A1m1 rs4646903 CYP1A2m1 rs1048943 CYP1A2m4 rs1799814 CYP1A2_154 rs762551 CYP1A2_3859 rs2069514 EPHX1Y113H rs1051740 EPHX1H139R rs2234922 NAT2_5A rs1799929 NAT2_6A rs1799930 NAT2_7AB rs1799931 SUL1A1R213H rs9282861 GSTM1 GSTT1 | sex age DNA Adducts (32P postlabelling) | |
| EPIC Heidelberg Principal Investigator: Jakob Linseisen, 102 premenopausal women of the EPIC-Heidelberg cohort study; WBC DNA was used for the analysis of etheno-DNA adducts; Scientific aim: to investigate the association between fatty acid intake and lipid-peroxidation derived DNA adducts. | Germany | sex age smoking etheno-desoxyadenosine etheno-desoxycytosine Energy intake, kcal/day Energy intake, kJ/day Alcohol intake, g/day Protein intake, g/day Total fat intake, g/day Carbohydrate intake, g/day Fatty acid intake, 16:0, mg/day Fatty acid intake, 18:0, mg/day Fatty acid intake, 18:1, mg/day Fatty acid intake, 18:2, mg/day Fatty acid intake, 18:3, mg/day Fatty acid intake, 20:3, mg/day Fatty acid intake, 20:4, mg/day Fatty acid intake, 20:5, mg/day Fatty acid intake, 22:5, mg/day Fatty acid intake, 22:6, mg/day | ||
| DNA Adducts in smokers Principal Investigator: Roger Godschalk, Frederik-Jan Van Schooten Dataset of DNA adducts in human lung, bronchoalveolar lavages and lymphocytes in various smoking populations. Whenever possible 4-aminobiphenyl-hemoglobin adduct levels and genetic polymorphisms are included. | cp1a2_1f rs762551 gstm1 gstt1 gstp1_2 rs947894 gstp1_3 rs1799811 nat2_5 rs1801280 nat2_6 rs1799930 nat2_7 rs1799931 xrcc1_2 xrcc1_3 xrcc1_4 xrcc3_1 xpd5 brca2_1 brca2_3 gpx rs1050450 meh2 rs1051740 meh3 rs2234922 nqo1 rs1800566 cyp1a1m1 cyp1a1m2 rs1048943 cyp1a1m4 rs1799814 cyp1b1_5 rs1056836 cyp1b1_7 rs1800440 cyp3a4 rs2740574 cyp2e1 rs6413420 mpo rs2333227 | smoking age sex DNA Adducts (RAL) 4 ABP Hb | ||
| Diet, Cancer and Health (Lung Cancer) Principal Investigator: Ulla Vogel, Diet, Cancer and Health (DCH) is a Danish prospective follow-up study. Between 1993-1997, 160,725 individuals aged 50-64 years were invited to participate, from which 57,053 individuals with no previous cancer diagnosis were recruited. | Denmark | Lung cancer | xpde23 xpde10 xpa xpc ercc1 ogg gpx GSTT1 GSTM1 | |
| Diet, Cancer and Health (ColoRectal Cancer) Principal Investigator: Ulla Vogel, Diet, Cancer and Health (DCH) is a Danish prospective follow-up study. Between 1993-1997, 160,725 individuals aged 50-64 years were invited to participate, from which 57,053 individuals with no previous cancer diagnosis were recruited. | Denmark | Colorectal Cancer | XPDE_K751Q XPDE_D312N XPA_A_23G XPC_K939Q ERCC1_A118A | sex |
| Bulky PAH-DNA Adducts and Bladder Cancer Principal Investigator: Roel Vermeulen, Investigated the relation between bulky PAH-DNA adducts in peripheral blood mononuclear cells and bladder cancer in non-smoking subjects from a large hospital-based case-control study in Spain. Additionally, we examined the association between DNA adduct | Spain | Bladder cancer | Average adduct level of first observed adduct Average adduct level of second observed adduct Average adduct level of third observed adduct Average adduct level of fourth observed adduct Average adduct level of fifth observed adduct Average adduct level of sixth observed adduct Average adduct level of seventh observed adduct Average adduct level of eight observed adduct sex age smoking | |
| AULIS Principal Investigator: Georgiadis Panagiotis, 194 persons sampled twice (summer and winter) for a number of biomarkers: - Polymorphisms RLFP - Serum cotinine Radioimmunoassay - Urinary 1-hydroxypyrene (1-OHP) Extraction, hydrolysis, HPLC (umol/mol creatinine) - Bulky DNA adducts 32P-postlabelling | Greece | cyp2E1RSAI cyp1A1MSP1 cyp1A1EXON7 CYP1A1M3 CYP1B1B CYP1B1C CYP1B1D CYP1B1F XRCC1COR rs-- GSTM GSTP1 GSTT1 NQO1 HMEH3 HMEH4 NAT2 | Serum cotinine 1-OHPA (morning urine) 1-OHPC (evening urine) Bulky DNA adducts A (32P-postlabelling) Bulky DNA adducts B (32P-postlabelling) Lymphocyte HPRT mutations Lymphocyte SCE Lymphocyte chromosome aberrations age sex height weight BMI smoking Benzo[a]pyrene Sum of eight carcinogenic PAH | |
Principal Investigator: Ryszard Olinski, Dataset with biomarker values, together with case/control status for 551 subjects. Methods adopted: - Determination urinary excretion of 8-oxodG, 8-oxoGua - Determination of plasma vitamins A, E, C and uric acid concentration - Isolation of leukocytes | Poland | All tumors | sex age Ascorbic acid Uric acid Tocopherol Retiol 8 oxo dG 106 (leukocytes) 8 oxo dG 106 (cancer tissue) 8 oxo dG 106 (normal tissue) 8 oxoGua (urine) 8 oxo dG (urine) 5 metdC (leukocytes) 5 metdC (normal tissue) 5 metdC (cancer tissue) residence smoking |
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