MEC database

Construction and implementation of a knowledge data base on Molecular Epidemiology and Cancer. The projects currently included in MEC are accessible following the link.
 
 
 
 
StudyCountryType of tumourSNPExposures,Biomarkers,Others
Turin Bladder cancer study
Principal Investigator: Giuseppe Matullo,

Data on 350 cases and 350 controls regarding lifestile variables (smoking, diet) and DNA polymorphisms (DNA repair and metabolic genes); DNA adducts on a subset of subjects.
ItalyBladder cancerXRCC2_31479_A_G rs3218536
XPD_ERCC2_23591_G_A_ex23 rs1799793
XPD_ERCC2_35931_C_A_ex23 rs13181
PCNA_6084_G_C rs3626
XRCC1_26304_T_C rs1799782
XRCC1_26651_G_A rs915927
XRCC1_28152_G_A_ex10 rs25487
XRCC1 rs1001581
XRCC3_4541_C_T rs1799794
XRCC3_17893_A_G rs1799796
XRCC3_18067_C_T_ex7 rs86153
APEX_1738_T_G rs1130409
ERCC1_19007_C_T rs11615
XPA_23_A_G rs1800975
XPC_PAT
ERCC4_30028_C_T_Ser835Ser rs1799
ERCC4_30147_G_A_Glu875Gly rs1800
XRCC1 rs2854501
ERCC1 rs2336219
ERCC1 rs3212955
ERCC1 rs735482
ERCC2 rs171140
ERCC2 rs1799787
ERCC2 rs3916874
ERCC1 rs967591
ERCC2 rs1052555
NAT2_T_C rs1041983
NAT2_T_C rs1801280
sex
age
race
ethnicity
smoking
Parallel 24-day dietary study
Principal Investigator: Steffen Loft,

A parallel placebo-controlled intervention study in which subjects were randomized into three groups receiving an antioxidant-free basal diet and 600 g of fruits and vegetables, or a supplement containing the corresponding amounts of vitamins
DenmarkSex
Diet (Vitamins, Minerals)
Ogg1 repair activity
5 day sunflux prior to measurement
10 day sunflux prior to measurement
30 day sunflux prior to measurement
OGG1 (mRNA)
ERCC1 (mRNA)
8oxodG excretion
DNA strand breaks
EndoIII sites
FPG sites
H2O2 sites
NLCS GENRE
Principal Investigator: P.A. Van Den Brandt,

This dataset contains information of the mutational status of the VHL-gene in 235 cases with renal cell cancer from the Netherlands Cohort Study on Diet and Cancer.
Netherland Renal Cell cancersex
Mutation in the VHL gene
NLCS CREAM
Principal Investigator: P.A. Van Den Brandt,

This dataset contains information of the mutational status of the KRAS and APC genes and on expression of MLH1 of 734 cases with colorectal cancer from the Netherlands Cohort Study on Diet and Cancer.
Netherland Colorectal cancersex
age
KRAS mutation
KRAS activating mutation
APC stop codon mutation
APC mutation
MLH1 expression
NIEH Lung cancer study
Principal Investigator: Bernadette Schoket,

162 cases of cancer were observed. Data collected include: smoking habits, gender, cellular damage and genotypes for 14 SNPs
Hungary Lung CancerCYP2S1
MPO_463G__A
CYP1A1Ile462Val
NQO1_Pro187Ser
GSTT1
CYP1A1_MspI
GSTM1
GSTP1_Ile105_Val
CYP1B1_Leu432Val
CYP2C9_Arg144Cys
CYP2C9_Ile359Leu
XRCC1_Arg399Gln
p53_Arg72Pro_exon4
XPG_1104
XPD_751
MTHFR_C677T
age
sex
smoking
DNA Adducts (32P postlabelling - lung tumour tissue)
DNA Adducts (32P postlabelling - bronchial tissue)
DNA Adducts (32P postlabelling - lung normal tissue)
DNA Adducts (32P postlabelling - limphocyte)
DNA Adducts (32P postlabelling - border tumour tissue)
CIA Adducts (lung tumour tissue)
CIA Adducts (lung normal tissue)
KRAS mutation (lung tumour tissue)
KRAS mutation (lung normal tissue)
P53 Mutation
O4-etT Postlabelling Adducts
GENAIR
Principal Investigator: Paolo Vineis,

The study was established to investigate molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke, looking at non-smokers in EPIC.
ItalyLeukemia, Lung and Bladder cancerXPD23591x rs1799793
XPD35931x rs13181
PCNA6084x rs3626
X1_26304x rs1799782
X1_26651x rs915927
X1_28152x rs25487
X3_17893x rs1799796
X3_18067x rs86153
APX_1738x rs1130409
E1_19007x rs11615
MG127215x rs12917
OG1_8055x
BRCA1x
BRCA2x
NBS1x
RAD51x
RAD512x
RAD52x
XRCC2x rs3218536
LIG4x
LIG45x
t_p53x
mnSODy
NQO1y
COMTy
MPOy
SULT_1A1y
GSTM3y
GSTP1_105y
GSTP1_114y
cyp1a1y
cyp1b1y
GSTT1y
GSTM1y
nat2y
Road traffic exposure
DNA Adducts (32P postlabelling)
FIOH BC AH
Principal Investigator: Ari Hirvonen,

Data on breast cancer: 964 cases and controls with genotype data about SNPs of GST, NAT, VDR, XRCC1, XPD, CYP17, COMT, MnSOD, SULTA1. Besides, informations about gender and smoking is provided.
Finland Breast cancerGSTM1
GSTT1
GSTP1
GSTM3
GSTM3_63AC
NAT1
NAT2
NAT2_282
NAT2_341
VDRTaqI
VDRBsmI
VDRApaI
CYP17
COMT
MnSOD
SULT1A1
XRCC1280
XRCC1399
XPD
sex
smoking
age
EPIC Spain
Principal Investigator: Antonio Agudo,

The database consists of 296 subjects for which we measured DNA adducts (by 32P-postlabelling) and SNPs in some metabolic genes.
SpainCYP1A1m1 rs4646903
CYP1A2m1 rs1048943
CYP1A2m4 rs1799814
CYP1A2_154 rs762551
CYP1A2_3859 rs2069514
EPHX1Y113H rs1051740
EPHX1H139R rs2234922
NAT2_5A rs1799929
NAT2_6A rs1799930
NAT2_7AB rs1799931
SUL1A1R213H rs9282861
GSTM1
GSTT1
sex
age
DNA Adducts (32P postlabelling)
EPIC Heidelberg
Principal Investigator: Jakob Linseisen,

102 premenopausal women of the EPIC-Heidelberg cohort study; WBC DNA was used for the analysis of etheno-DNA adducts; Scientific aim: to investigate the association between fatty acid intake and lipid-peroxidation derived DNA adducts.
Germanysex
age
smoking
etheno-desoxyadenosine
etheno-desoxycytosine
Energy intake, kcal/day
Energy intake, kJ/day
Alcohol intake, g/day
Protein intake, g/day
Total fat intake, g/day
Carbohydrate intake, g/day
Fatty acid intake, 16:0, mg/day
Fatty acid intake, 18:0, mg/day
Fatty acid intake, 18:1, mg/day
Fatty acid intake, 18:2, mg/day
Fatty acid intake, 18:3, mg/day
Fatty acid intake, 20:3, mg/day
Fatty acid intake, 20:4, mg/day
Fatty acid intake, 20:5, mg/day
Fatty acid intake, 22:5, mg/day
Fatty acid intake, 22:6, mg/day
DNA Adducts in smokers
Principal Investigator: Roger Godschalk, Frederik-Jan Van Schooten

Dataset of DNA adducts in human lung, bronchoalveolar lavages and lymphocytes in various smoking populations. Whenever possible 4-aminobiphenyl-hemoglobin adduct levels and genetic polymorphisms are included.
cp1a2_1f rs762551
gstm1
gstt1
gstp1_2 rs947894
gstp1_3 rs1799811
nat2_5 rs1801280
nat2_6 rs1799930
nat2_7 rs1799931
xrcc1_2 rs1799782
xrcc1_3 rs25489
xrcc1_4 rs25487
xrcc3_1 rs861539
xpd5 rs1052559
brca2_1 rs1799943
brca2_3 rs144848
gpx rs1050450
meh2 rs1051740
meh3 rs2234922
nqo1 rs1800566
cyp1a1m1 rs4646903
cyp1a1m2 rs1048943
cyp1a1m4 rs1799814
cyp1b1_5 rs1056836
cyp1b1_7 rs1800440
cyp3a4 rs2740574
cyp2e1 rs6413420
mpo rs2333227
smoking
age
sex
DNA Adducts (RAL)
4 ABP Hb
Diet, Cancer and Health (Lung Cancer)
Principal Investigator: Ulla Vogel,

Diet, Cancer and Health (DCH) is a Danish prospective follow-up study. Between 1993-1997, 160,725 individuals aged 50-64 years were invited to participate, from which 57,053 individuals with no previous cancer diagnosis were recruited.
DenmarkLung cancerxpde23
xpde10
xpa
xpc
ercc1
ogg
gpx
GSTT1
GSTM1
Diet, Cancer and Health (ColoRectal Cancer)
Principal Investigator: Ulla Vogel,

Diet, Cancer and Health (DCH) is a Danish prospective follow-up study. Between 1993-1997, 160,725 individuals aged 50-64 years were invited to participate, from which 57,053 individuals with no previous cancer diagnosis were recruited.
DenmarkColorectal CancerXPDE_K751Q
XPDE_D312N
XPA_A_23G
XPC_K939Q
ERCC1_A118A
sex
Bulky PAH-DNA Adducts and Bladder Cancer
Principal Investigator: Roel Vermeulen,

Investigated the relation between bulky PAH-DNA adducts in peripheral blood mononuclear cells and bladder cancer in non-smoking subjects from a large hospital-based case-control study in Spain. Additionally, we examined the association between DNA adduct
SpainBladder cancerAverage adduct level of first observed adduct
Average adduct level of second observed adduct
Average adduct level of third observed adduct
Average adduct level of fourth observed adduct
Average adduct level of fifth observed adduct
Average adduct level of sixth observed adduct
Average adduct level of seventh observed adduct
Average adduct level of eight observed adduct
sex
age
smoking
AULIS
Principal Investigator: Georgiadis Panagiotis,

194 persons sampled twice (summer and winter) for a number of biomarkers: - Polymorphisms RLFP - Serum cotinine Radioimmunoassay - Urinary 1-hydroxypyrene (1-OHP) Extraction, hydrolysis, HPLC (umol/mol creatinine) - Bulky DNA adducts 32P-postlabelling
Greececyp2E1RSAI
cyp1A1MSP1
cyp1A1EXON7
CYP1A1M3
CYP1B1B
CYP1B1C
CYP1B1D
CYP1B1F
XRCC1COR rs--
GSTM
GSTP1
GSTT1
NQO1
HMEH3
HMEH4
NAT2
Serum cotinine
1-OHPA (morning urine)
1-OHPC (evening urine)
Bulky DNA adducts A (32P-postlabelling)
Bulky DNA adducts B (32P-postlabelling)
Lymphocyte HPRT mutations
Lymphocyte SCE
Lymphocyte chromosome aberrations
age
sex
height
weight
BMI
smoking
Benzo[a]pyrene
Sum of eight carcinogenic PAH

Principal Investigator: Ryszard Olinski,

Dataset with biomarker values, together with case/control status for 551 subjects. Methods adopted: - Determination urinary excretion of 8-oxodG, 8-oxoGua - Determination of plasma vitamins A, E, C and uric acid concentration - Isolation of leukocytes
PolandAll tumorssex
age
Ascorbic acid
Uric acid
Tocopherol
Retiol
8 oxo dG 106 (leukocytes)
8 oxo dG 106 (cancer tissue)
8 oxo dG 106 (normal tissue)
8 oxoGua (urine)
8 oxo dG (urine)
5 metdC (leukocytes)
5 metdC (normal tissue)
5 metdC (cancer tissue)
residence
smoking